Observe that
$$3^{10-r}=(\sqrt3)^{20-2r}$$
Therefore
$$S=\sum_{r=0}^{10}\binom{20}{2r}(\sqrt3)^{20-2r}(-1)^r$$
Now use the standard identity
$$\frac{(a+b)^{20}+(a-b)^{20}}{2}=\sum_{r=0}^{10}\binom{20}{2r}a^{20-2r}b^{2r}$$
Take
$$a=\sqrt3,\qquad b=i$$
Since
$$i^{2r}=(-1)^r$$
we get
$$S=\frac{(\sqrt3+i)^{20}+(\sqrt3-i)^{20}}{2}$$
Now write
$$\sqrt3+i=2\left(\cos\frac{\pi}{6}+i\sin\frac{\pi}{6}\right)$$
Hence by De Moivre's theorem,
$$\left(\sqrt3+i\right)^{20}=2^{20}\left(\cos\frac{20\pi}{6}+i\sin\frac{20\pi}{6}\right)$$
Similarly,
$$\left(\sqrt3-i\right)^{20}=2^{20}\left(\cos\frac{20\pi}{6}-i\sin\frac{20\pi}{6}\right)$$
Adding,
$$S=\frac{2^{20}\left(2\cos\frac{20\pi}{6}\right)}{2}$$
$$=2^{20}\cos\frac{20\pi}{6}$$
$$=2^{20}\cos\frac{10\pi}{3}$$
$$=2^{20}\cos\frac{4\pi}{3}$$
$$=2^{20}\left(-\frac12\right)$$
$$=-2^{19}$$
Final Answer :
$$-2^{19}$$