As 2 characters are alphabets and 2 are numbers, the remaining 2 can be either numbers or alphabets. Hence, three cases exist.
Case 1: Both the remaining characters are alphabets
Hence the plate will have 4 alphabets and 2 numbers. The 4 alphabets can be chosen in $$^{26}C_{4}$$ ways. The 2 numbers can be chosen in $$^{10}C_{2}$$ ways. Hence, number of ways of selection under case 1 = $$^{26}C_{4}$$ * $$^{10}C_{2}$$
Case 2: Both the remaining characters are numbers
Hence the plate will have 2 alphabets and 4 numbers. The 2 alphabets can be chosen in $$^{26}C_{2}$$ ways. The 4 numbers can be chosen in $$^{10}C_{4}$$ ways. Hence, number of ways of selection under case 2 = $$^{26}C_{2}$$ * $$^{10}C_{4}$$
Case 3: One character is a number and one is an alphabet
Hence the plate will have 3 alphabets and 3 numbers. The 3 alphabets can be chosen in $$^{26}C_{3}$$ ways. The 3 numbers can be chosen in $$^{10}C_{3}$$ ways. Hence, number of ways of selection under case 3 = $$^{26}C_{3}$$ * $$^{10}C_{3}$$
In each of the cases, as there is no repetition, the arrangement can be done in 6! ways.
Hence, total number of plates = 6! * ($$^{26}C_{4}$$ * $$^{10}C_{2}$$ + $$^{26}C_{2}$$ * $$^{10}C_{4}$$ + $$^{26}C_{3}$$ * $$^{10}C_{3}$$)