Question 29

The five sentences labelled (1, 2, 3, 4, 5) given in this question, when properly sequenced, form a coherent paragraph. Each sentence is labelled with a number. Decide on the proper order for the sentences and key in this sequence of five numbers as your answer.

1. Scientists have for the first time managed to edit genes in a human embryo to repair a genetic mutation, fuelling hopes that such procedures may one day be available outside laboratory conditions.
2. The cardiac disease causes sudden death in otherwise healthy young athletes and affects about one in 500 people overall.
3. Correcting the mutation in the gene would not only ensure that the child is healthy but also prevents transmission of the mutation to future generations.
4. It is caused by a mutation in a particular gene and a child will suffer from the condition even if it inherits only one copy of the mutated gene.
5. In results announced in Nature this week, scientists fixed a mutation that thickens the heart muscle, a condition called hypertrophic cardiomyopathy.

Correct Answer: 15243


After reading all the given sentences, we know that the paragraph is about the gene editing and a specific disease where the process has been used effectively. Statement 1 is the opening sentences introducing the topic that how for the first time scientists have managed to edit gene. Statement 5 provides the specifics of the case where the gene editing has taken place. 'The cardiac disease' mentioned in statement 2 refers to hypertrophic cardiomyopathy discussed in statement 5. So, statement 2 must follow statement 5. Statement 4 explains the causes of the of the disease mentioned in statement 2. Statement 3 is a conclusion about the result of the process explained earlier. Thus, the correct order is 1 - 5 - 2 - 4 - 3.
Hence, 15243 is the correct answer.

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