Middle number = (Difference between the numbers written on left hand side)*(Sum of the numbers written on right hand side)
80 = (15 - 5)*(2 + 6)
65 = (9 - 4)*(7 + 6)
Therefore, ? = (13 - 11)*(16 + 8) = 2*24 = 48.
Hence, option B is the correct answer.
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