Select the option that is related to the fifth alphanumeric-cluster in the same way as the second alphanumeric-cluster is related to the first alphanumeric-cluster and the fourth alphanumeric-cluster is related to the third alphanumeric-cluster.

I81 : K121 :: D16 : F36 :: O225 : ?

A

Q289

B

P256

C

R324

D

P265