Which two signs and two numbers should be interchanged in the following equation to make it correct?
$$78 + 456 − 45 \times 12 \div 4 = 519$$

A

12 and 4, − and $$\times$$

B

78 and 456, $$\div$$ and $$\times$$

C

45 and 12, + and $$\div$$

D

456 and 45, $$\div$$ and −