Three of the following sentences in the options form a coherent passage. Choose the option that contains the irrelevant sentence.

Another feature is the extremely complex causal basis of many diseases, which hampers the effectiveness of interventions on those diseases.

A prominent feature of medicine is the hope and expectation of patients that medicine can help them, coupled with the training of physicians to actively intervene.

The pharmaceutical industry is extremely profitable, and the fantastic gains to be made from selling drugs create incentives to engage in some questionable practices.

The history of science shows that major scientific revolutions typically occur without no thought of reward - think of Copernicus, Newton, Darwin and Einstein - breakthroughs in medicine are no different.