In the following passage some of the words have been deleted. Read the passage carefully and select the correct answer for the given blank out of the four alternatives.

An 'occupational disease' is any disease (1) __________ primarily by exposure at work (2) __________ a physical, organisational, chemical or biological risk (3) __________ or to a combination of these factors. Occupational diseases are (4) __________ those listed in national legislation as resulting from exposure to risk factors at (5) __________ .