In the following passage, some words have been deleted. Read the passage carefully and select the most appropriate option to fill in each blank.

Isolation and loneliness (1) ________ by the Covid-19 pandemic and lockdown policies negatively (2) _______ the mental health of the public throughout the entire globe. These result in an increase in emotional (3) __________, (4) __________ of hopelessness and extreme anxiety, which are (5) _______ by variations in emotional responses and style of living.