After the change process, which course among E1 to E6 had the largest change in its enrollment as a percentage of its original enrollment?

From the table we can say that number of students who opted for E2 after reshuffle = 5 + 34 + 6 + 3 + 5 + 7 + 16 = 76. 

It is given us that the number of students in E2 increased by 30 after the change process. Hence, we can say that the number of students who were enrolled in E2 before reshuffle = 76 - 30 = 46. 

It is given that before the change process there were 10 more students in E2 than in E3. Therefore, the number of students who were enrolled in E3 before reshuffle = 46 - 10 = 36. 

Number of students who moved from E1 to all other electives are known. Therefore, the number of students who were enrolled in E1 before reshuffle =  9 + 5 + 10 + 1 + 4 + 2 = 31. 

It is given that before the change process there were 6 more students in E1 than in E4. Therefore, the number of students who were enrolled in E4 before reshuffle = 31 - 6 = 25. 

Also, it is given that E4 had 2 more students than E6 before reshuffle. Therefore, the number of students who were enrolled in E6 before reshuffle =  25 - 2 = 23. 

All the students from E7 moved to one of electives among E1 to E6.  Therefore, the number of students who were enrolled in E7 before reshuffle = 4 + 16 + 30 + 5 + 5 + 41 = 101. 

Except E5 we know the number of students who were enrolled in all electives. We also know that there were total 300 students who opted for exactly 1 elective. 

Hence, the the number of students who were enrolled in E7 before reshuffle = 300 - (46+36+31+25+23+101) = 38. 

For each elective, the number of students who were enrolled before reshuffle will be same as sum of the number of students who moved from that elective to another elective including no movement cases. 

For elective E2,

Number of students who moved to E1 + 34 + 8 + Number of students who moved to E4 + 2 + 2 = 46 

i.e. Number of students who moved from to E1 =  Number of students who moved from to E4 = 0

For elective E4,

Number of students who moved to E1 + 3 + 2 + 14 + Number of students who moved to E5 + 4 = 25 

i.e. Number of students who moved from to E1 =  Number of students who moved from to E5 = 1     {As the remaining blanks can be filled by either 0 or 1}

For elective E6,

Number of students who moved to E1 + 7 + 3 + Number of students who moved to E4 + 2 + 9 = 23

i.e. Number of students who moved from to E1 =  Number of students who moved from to E4 = 1     {As the remaining blanks can be filled by either 0 or 1}

It is given that after the reshuffle, the number of students in E4 was 3 more than that in E1. As of now the number of students enrolled in E4 after reshuffle = 1 + 0 + E3 to E4 + 14 +  E5 to E4 + 1 + 5 = 21 + {E3 to E4} + {E5 to E4}

Also, the number of students enrolled in E1 after reshuffle = 9 + 0 + 2 + 1 + E5 to E1 + 1 + 4  = 17 + E5 to E1. 

Hence, it is possible only when  E5 to E1 = 1 and E3 to E4 = E5 to E4 = 0. 

Remaining blank places can be filled easily as we know the total sum of each row. 

Therefore, the number of students who moved from E3 to E5 = the number of students who moved from E5 to E3 = the number of students who moved from E5 to E6 = 1.

We are asked the largest change in its enrollment as a percentage of its original enrollment for all 6 electives but as we can see there are only 4 electives. Hence, we will check only for E1, E2, E3 and E6. 

The percentage change in the number of students for E1 = $$\dfrac{18-31}{31}\times 100$$ $$\approx$$ 42 %

The percentage change in the number of students for E2 = $$\dfrac{76-46}{46}\times 100$$ $$\approx$$ 65 % 

The percentage change in the number of students for E3 = $$\dfrac{79-36}{36}\times 100$$ $$\approx$$ 119 % 

The percentage change in the number of students for E6 = $$\dfrac{61-23}{23}\times 100$$ $$\approx$$ 165 % 

We can see that the percent change in the number of student for E6 is the largest. Therefore, option D is the correct answer.