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"those who" is grammatically correct because "who had previously challenged his leadership" refers to people.
The other options are incorrect due to improper pronoun usage: "they who" and "them who" are incorrect; "they" and "them" are subject and object pronouns, respectively, and do not fit properly here. "he who" is incorrect because "he" is a subject pronoun, but the phrase requires a demonstrative pronoun ("those"). "that who" is incorrect because "that" refers to things, not people.
Answer is option D.
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