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Step 1: Reduction of the Nitrile with Ni/H2 Nickel with hydrogen gas (Ni/H2) is used to reduce the nitrile group selectively while leaving the ester group untouched.
Step 2: Ring Closure (Cyclization) The molecule now contains a nucleophilic amine group (NH2) and an electrophilic ester group (COOEt) right next to each other.
Step 3: Reduction with DIBAL-H Diisobutylaluminum hydride (DIBAL-H) is a selective, bulky reducing agent. When it reacts with a cyclic amide (lactam), it reduces the carbonyl group (C=O).
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