The statement/s which are true about antagonists from the following is/are:
A. They bind to the receptor site.
B. Get transferred inside the cell for their action.
C. Inhibit the natural communication of the body.
D. Mimic the natural messenger.
Choose the correct option from the options given below:

We need to identify which statements are true about antagonists in pharmacology.

An antagonist is a drug that binds to a receptor but does not activate it. Instead, it blocks the receptor and prevents the natural agonist (messenger) from binding and producing its effect.

Let us evaluate each statement:

Statement A: "They bind to the receptor site."

This is TRUE. Antagonists bind to the receptor site on the cell surface. This binding is essential for their blocking action.

Statement B: "Get transferred inside the cell for their action."

This is FALSE. Antagonists act at the receptor level on the cell surface. They do not need to enter the cell to exert their effect. They simply block the receptor from the outside.

Statement C: "Inhibit the natural communication of the body."

This is TRUE. By blocking the receptor, antagonists prevent the natural messenger (agonist) from binding and transmitting its signal. This effectively inhibits the natural communication pathway of the body.

Statement D: "Mimic the natural messenger."

This is FALSE. It is the agonists that mimic the natural messenger and activate the receptor. Antagonists do the opposite -- they block the receptor without activating it.

Therefore, statements A and C are true about antagonists.

The correct answer is Option C: A and C.