Most of the biological molecules, are thermodynamically unstable to hydrolysis but, nevertheless, spontaneously hydrolyze at biologically insignificant rates because:

A large negative value of Delta G does not ensure a chemical reaction will proceed at a measurable rate. This depends on the detailed mechanism of the reaction, which is independent of Delta G.

A large position value of Delta G does ensure a chemical reaction will proceed at a measurable rate. This depends on the detailed mechanism of the reaction, which is dependent of Delta G.

A large negative value of Delta G does ensure a chemical reaction will proceed at a measurable rate. This depends on the detailed mechanism of the reaction, which is dependent of Delta G.

A large positive value of Delta G does ensure a chemical reaction will proceed at a measurable rate. This depends on the detailed mechanism of the reaction, which is independent of Delta G.