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Question 45

Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R:
Assertion A: Acetal/Ketal is stable in basic medium.
Reason R: The high leaving tendency of alkoxide ion gives the stability to acetal/ketal in basic medium.
In the light of the above statements, choose the correct answer from the options given below:

Assertion A: Acetal/Ketal is stable in basic medium. — TRUE. Acetals and ketals are stable under basic conditions but hydrolyze under acidic conditions.

Reason R: The high leaving tendency of alkoxide ion gives stability to acetal/ketal in basic medium. — FALSE. Alkoxide ions are actually poor leaving groups (high pKa ~16). The stability in basic medium is because the first step of hydrolysis requires protonation of the oxygen (acid catalysis), which doesn't occur in basic conditions.

Since A is true and R is false, the correct answer is Option A: $$\boxed{\text{A is true but R is false}}$$.

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