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We need to identify the compound that does NOT contain a sulphur atom. Histamine has the molecular formula $$C_5H_9N_3$$ and is an imidazole derivative (2-(1H-imidazol-4-yl)ethanamine). It contains only C, H, and N atoms, with no sulphur atom present.
Cimetidine is an $$H_2$$ receptor antagonist (antihistamine drug) with molecular formula $$C_{10}H_{16}N_6S$$ and contains a sulphur atom in its thioether linkage; saccharin is an artificial sweetener with the molecular formula $$C_7H_5NO_3S$$ and contains a sulphur atom in its sulfonamide group; and ranitidine, another $$H_2$$ receptor antagonist, has the molecular formula $$C_{13}H_{22}N_4O_3S$$ and also contains a sulphur atom.
Among the given compounds, only histamine lacks a sulphur atom. The correct answer is Option A: Histamine.
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